GEOTOP-A SEMINAR SERIES


Speaker: De Witt L. Sumners
Title: DNA Topology
Keywords: DNA, topoisomerase, site-specific recombination, knots, links, tangle model, supercoiling, viral capsids
Date: August 17, 2018


Cellular DNA is a long, thread-like molecule with remarkably complex topology. Enzymes that manipulate the geometry and topology of cellular DNA perform many vital cellular processes (including segregation of daughter chromosomes, gene regulation, DNA repair, and generation of antibody diversity). Some enzymes pass DNA through itself via enzyme-bridged transient breaks in the DNA; other enzymes break the DNA apart and reconnect it to different ends. In the topological approach to enzymology, circular DNA is incubated with an enzyme, producing an enzyme signature in the form of DNA knots and links. By observing the changes in DNA geometry (supercoiling) and topology (knotting and linking) due to enzyme action, the enzyme binding and mechanism can often be characterized. This talk will discuss topological models for DNA strand passage and exchange, including the analysis of site-specific recombination experiments on circular DNA and the analysis of packing geometry of DNA in viral capsids.





Speaker: Rafael Herrera
Title: A brief introduction to Discrete Exterior Calculus
Keywords: differential forms, Hodge star operator, simplicial complex, boundary operator
Date:September 7, 2018


Discrete Exterior Calculus (DEC) is a relatively new method for solving partial differential equations numerically. The central idea of the method is to develop a discrete version of Exterior Differential Calculus. In this talk, we will briefly review the various operators of Exterior Differential Calculus and their discrete versions. We will then focus our attention in 2D DEC, presenting a geometric interpretation of DEC as well as numerical comparisons with the Finite Element Method in order to show DEC’s competitive performance.





Speaker: Cristian Micheletti
Title: Knotted DNA: conformational, dynamical and pore-translocation properties
Keywords: pore translocation, DNA knots, DNA supercoiling
Date: September 21, 2018


Knots and supercoiling are both introduced in bacterial plasmids by catalytic processes involving DNA strand passages. I will report on a recent study where we used molecular dynamics simulations and a mesoscopic DNA model, to study the simultaneous presence of knots and supercoiling in DNA rings and the kinetic and metric implications which may be relevant for the simplyfing action of topoisomerases. Finally, I will discuss how the same modelling and simulation approach can be used shed light on the complex experimental phenomenology of knotted DNA translocating through solid state nanopores.





Speaker: Vidit Nanda
Title: Discrete Morse Theory
Keywords: discrete Morse theory, persistent homology, cellular sheaf theory, flow category
Date: October 19, 2018


Large-scale homology computations are rendered tractable in practice by a combinatorial version of Morse theory. Assuming that my internet connection survives, in this talk I will introduce discrete Morse theory, describe how it helps with computing various types of homology, and outline a powerful new higher-categorical extension. The audience will not require prior knowledge of any of the technical terms mentioned above.





Speaker: Jesus Gonzalez
Title: Simplicial complexity: piecewise linear motion planning in robotics.
Keywords: topological complexity, simplicial topology, simplicial aproximation, contiguity of maps
Date: November 9, 2018


Using the notion of contiguity of simplicial maps, and its relation (via iterated subdivisions) to the notion of homotopy between continuous maps, we adapt Farber's topological complexity to the realm of simplicial complexes. We show that, for a finite simplicial complex K, our discretized concept recovers the topological complexity of the realization of K.